Yes. Long-term marijuana use can lead to addiction in some people. That is, they cannot control their urges to seek out and use marijuana, even though it negatively affects their family relationships, school performance, and recreational activities (9). According to one study, marijuana use by teenagers who have prior antisocial problems can quickly lead to addiction (3). In addition, some frequent, heavy marijuana users develop â€œtoleranceâ€ to its effects. This means they need larger and larger amounts of marijuana to get the same desired effects as they used to get from smaller amounts.